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KMID : 0391520130210010001
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Journal of the Korean Child Neurology Society
2013 Volume.21 No. 1 p.1 ~ p.6
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Effectiveness and Tolerability of Fosphenytoin for Pediatric Status Epilepticus
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Hong Won-Gi
Yoo Il-Han
Kim Jon-Soo
Ryu Hye-Won
Byun Sung-Hwan
Kim Hun-Min
Lim Byung-Chan
Chae Jong-Hee
Choi Ji-Eun
Kim Ki-Joong
Hwang Yong-Seung
Hwang Hee
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Abstract
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Purpose: The study was aimed to investigate the effectiveness and tolerability of intravenous fosphenytoin (fPHT) in the treatment of pediatric status epilepticus (SE).
Methods: Medical-records of patients who received intravenous (IV) fPHT for the treatment of SE were retrospectively reviewed and their clinical data were analyzed regarding age, gender, seizure types, underlying neurologic status, use of other anticonvulsants, loading dose, response and adverse events of IV fPHT.
Results: Twenty patients (12 boys and 8 girls) were included in the study. The mean age at administration of IV fPHT was 3.98 years (range 0-18.6 years). Of the 20 patients, 15 patients had no underlying neurological conditions, but five patients were on anticonvulsants. IV fPHT terminated the seizures in 15 of the 20 patients (75%). No adverse events occurred during or after the infusions.
Conclusion: This study demonstrated that IV fPHT was as effective as phenytoin and was well-tolerated in the treatment of pediatric SE. IV fPHT can be considered as a substitute for phenytoin in the management of pediatric SE.
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KEYWORD
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Fosphenytoin, Pediatric, Status Epilepticus, Effectiveness, Tolerability
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